APP and dementia: Although the sample size of these studies was small and the minority were carriers of A431E, it is important to highlight that the neuropathological findings in postmortem studies allow in the first instance the differentiation between EOAD due to A431E variant or others in PSEN1, and variants in PSEN2 or APP, SAD, and dementias caused by other conditions such as PPA and bvFTD (Gefen et al., 2020), and may ultimately be of help for the differential diagnosis (Braak and Braak, 1991; McKhann et al., 2011).