APP and dementia: Control subjects (n = 11). Carriers without dementia (n = 22) of variants A431E (n = 14), L235V and G206A (n = 3) associated with PSEN1 and the V717I APP variant (n = 5). Carriers with dementia (n = 3), A431E (n = 1), L235V and G206A (n = 2).