In the clinical, a higher prevalence of headaches in MCs is held for different PSEN1 and APP mutations (Ringman et al., 2008a) and electrophysiological features related to longer latencies of the N100, P200, N200, and P300 components, and smaller slow wave amplitudes (Golob et al., 2009). This evidence concerns the gene PSEN1 and Headache.