In the present study, Vit D treatment enhanced Notch1–HIF‐1α expression in lung tissue, as well as accelerated autophagy, reduced airway hyperreactivity, and alleviated airway inflammation and remodeling; these findings indicated that facilitating Notch1–HIF‐1α expression might be an important target for Vit D‐mediated regulation of autophagy during treatment of RSV‐induced asthma. This evidence concerns the gene NOTCH1 and asthma.