As shown in a previous Litopenaeus vannamei challenge using Vibrio harveyi (Huang et al., 2013), despite the common reduction of SOD activity, THC, and PO activity during early infection time points, increased levels of SOD activity, THC, and PO activity were detected in disease‐resistant shrimps compared to non‐resistant shrimps. The gene discussed is SOD1; the disease is infection.