SIRT1 and metabolic disease: Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase (HDAC), has been shown to regulate multiple biological processes including aging, inflammation, autophagy, cancer, and metabolic diseases (Canto and Auwerx, 2009; Knight and Milner, 2012; Nogueiras et al., 2012; Singh and Ubaid, 2020; Wang et al., 2021).