NMJ dysfunction, paralysis and degeneration also occur following acute exposure to agricultural insecticides containing organophosphorus (OP) anti-AChE compounds dissolved in organic solvents, with possible links to ALS (Eddleston et al., 2012; Pamphlett, 2012; Merwin et al., 2017; Dissanayake et al., 2021a,b). This evidence concerns the gene ACHE and amyotrophic lateral sclerosis.