It would be of interest to study the molecular pathways and biological processes mediated by ARHGEF39 in these cell populations to understand its role in neurodevelopment, particularly since changes in Rho GTPase activation have emerged as a molecular hub in various neurodevelopmental disorders (Zhao et al., 2015; Zamboni et al., 2018). This evidence concerns the gene ARHGEF39 and neurodevelopmental disorder.