This valence-dependent PFC hemodynamic response to emotional stimuli in patients with BD was also reported in an fNIRS study with the emotional Stroop paradigm, where patients with BD showed decreased oxy-Hb in the bilateral middle frontal region responding to happy words and increased oxy-Hb in the left inferior frontal region responding to threat words (Matsubara et al., 2014). The gene discussed is GSTM1; the disease is Behcet disease.