Interestingly, one study found that 15 of 46 Ménière’s disease families (33%) showed at least one rare missense variant in the OTOG gene, a finding that supports OTOG as an associated gene in familial Ménière’s disease and lays the foundation for genetic testing for Ménière’s disease (Roman-Naranjo et al., 2020). Here, OTOG is linked to Meniere disease.