Previous studies reveal that Nogo-B plays an important role in many diseases like atherosclerosis (Rodriguez-Feo et al., 2007), cancer, childhood epilepsy, and neurodegenerative disease (Eckharter et al., 2015; Zhang et al., 2020), and its potential as a novel candidate gene of Parkinson's disease (Guo et al., 2018). This evidence concerns the gene RTN4 and Parkinson disease.