To validate our data on whether the binding affinity of standard tetracyclines, cephalosporins, and phytochemicals toward the SARS-COV2 can be pharmacologically effective or not, we have compared the binding affinity of minocycline with COVID-19 main protease to the binding affinity of minocycline against NS3 helicase/ nucleoside triphosphatase of Japanese encephalitis (J.E.), which possesses enzymatic activities of a serine protease, helicase, and nucleoside 5'-triphosphatase (NTP). The gene discussed is KRAS; the disease is Japanese encephalitis.