GRIA4 and Intellectual disability: Neuro development-related disorders such as intellectual disability (ID) and language impairment can happen due to disruption of glutamatergic synaptic transmission caused by glutamate ionotropic genes (GRIA2, GRIA4, GRIA1, and GRIA3), as these postsynaptic ionotropic receptors arbitrate rapidly excitatory currents (Rinaldi et al., 2022).