In addition, we found some bridging genes between symAD vs. control and symAD vs. AsymAD that were overlapping in these two comparative groups: RPS6, RPS18, RPS3A, RPS24, and RPL9. Whereas AsymAD vs. control groups showed unique gene signatures, suggesting the onset of AD progression to be exclusively restricted to AsymAD. This evidence concerns the gene RPS6 and Alzheimer disease.