The dysregulation of U3 small nucleolar ribonucleoproteins genes (SNORD3B-1, SNORD3A, SNORD3B-2, SNORD3C, and SNORD3D) are related to age-related immune dysfunction (Rahmatpanah et al., 2019), G0/G1 to S phase transition (Valleron et al., 2012), oxidative-/ER-stress (23349890), and pathogenesis of AD (Fitz et al., 2021). The gene discussed is SNORD3B-2; the disease is Alzheimer disease.