SERPING1 and hereditary angioedema: Examples of such situations are the combination of SERPING1 variants with the F12-c.-4C>T polymorphic variant (rs1801020; MAF 0.472) (49, 50) and that of the c.513 + A>G SERPING1 variant with the F12-c.1032C>A;p(Thr328Lys) pathogenic variant presenting HAE symptoms since 7 years of age with a severe phenotype (51).