The protein interaction network included PYGB, FABP5, ITGA4, ITGA9, RBX1, ARF6, PAK4, GIT1, and COMMD8, which are associated with cell proliferation, cell migration, and invasion, thereby indicating that the expression of proteins associated with metastasis and invasion occurs during cancer development from CNAG to GIN. Here, COMMD8 is linked to cancer.