CD4 and neoplasm: Given the pivotal role of CD4+ and CD8+ DC-CIK cells in tumor immunity, the effect of the Tim-3 and PD-1 blockades on the function of DC-CIK cells was explored by determining the expression rate of CD4+ and CD8+ DC-CIK cells in the Tim-3 blockade group, the PD-1 blockade group, and the Tim-3+PD-1 blockade group.