The main objective of the current experiment was to explore the theories of lncRNA-HCG18 in cell proliferation of myocardial fibroblasts and to determine the effect and interactions of the hsa-miR-133a/EGFR axis in the lncRNA-HCG18-mediated addition of myocardial infarction cells. This evidence concerns the gene HCG18 and myocardial infarction.