This study also determined evidently lower fovea thickness and VEGF level in aqueous humor in RG, indicating that the combination of Lucentis and PPV could significantly ameliorate the macular edema and the VEGF level in aqueous humor, which may be due to the selective combination of Lucentis with VEGF to play a role in inhibiting angiogenesis. The gene discussed is VEGFA; the disease is macular retinal edema.