The results showed that the level of fibronectin in the NRK-52E cells significantly increased after TGF-β1 stimulation, suggesting the occurrence of renal fibrosis, while the expression level of FN decreased after the dosages 0.8 and 1.6 mg/ml drug concentration of DSS treatment, suggesting that DSS can treat renal fibrosis. Here, FN1 is linked to renal fibrosis.