The epigenetic target screening using the shRNA (short-hairpin RNA) library and genome-wide CRISPR library proves that the BET (bromodomain and extraterminal) protein family member BRD4 (bromodomain containing 4) is the most important member of the BET family of histone reading proteins, which is essential to maintain AML [4, 5]. The gene discussed is BRD4; the disease is acute myeloid leukemia.