It was also found that the elevated levels of Bcl-2 protein are responsible for the persistence of eosinophils and neutrophils during allergic airway inflammation Furthermore, the Bcl-2 inhibitor ABT-737 and ABT-199 may inhibit allergic airway inflammation by promoting the death of inflammatory cells, especially in asthma dominated by neutrophils and insensitive to corticosteroids (108). This evidence concerns the gene BCL2 and asthma.