On the other hand, other AD transgenic mice, harboring mutations in APP, presenilin 1 (PS1), and tau, show a rapidly progressing pathology with deposition of Aβ in plaques beginning much earlier, at 4–6 months of age, and with significant learning and memory deficits (Sasaguri et al., 2022). This evidence concerns the gene PSEN1 and Alzheimer disease.