RIPK3 and malignant mesothelioma: RIPK3 may act as a tumor suppressor to inhibit malignant progression of malignant mesothelioma through induction of necrotic apoptosis, whereas RIPK3 DNA epigenetic silencing of methylation impairs necroptosis and leads to chemoresistance as well as poorer prognosis in malignant mesothelioma (115).