TGFB1 and Miyoshi myopathy: One possible mechanism is that TGF-β suppression stimulates collagen maturation to increase bone repair and fracture resistance, and another mechanism is that TGF-β suppression can release stromal cells from the differentiation block of MM and induce osteoblast differentiation, which inhibits the proliferation and survival of MM cells, increases the sensitivity of MM cells to chemotherapeutic drugs, and overcomes stromal cell-mediated drug resistance (135, 136).