Normatively, the natural history can be divided into four consecutive phases under the conventional criteria of serum hepatitis B e antigen (HBeAg) status, HBV DNA, and alanine transferase (ALT) levels, which are HBeAg-positive non-significant hepatitis activity (NSHA), HBeAg-positive significant hepatitis activity (SHA), HBeAg-negative NSHA, and HBeAg-negative SHA (3–6). This evidence concerns the gene GPT and hepatitis A virus infection.