CALCA and asthma: Moreover, the Th2 cytokines in BALF of HDM-stimulated wild-type mice increased by 6.6-fold for IL-4, 3.4-fold for IL-5 and 4.8-fold for IL-13, respectively, along with 10.6-fold elevation of pro-inflammatory cytokine KC (human IL-8 homologue), which was believed to be the main effector cytokine to recruit neutrophils in asthma.