In the COVID-19 dataset, TYMS(AUC:0.952), RRM2(AUC:0.954), CDCA2(AUC:0.946) and TOP2A(AUC:0.958) exhibited good diagnostic efficiency for differentiating the patients with SARS-CoV-2 from healthy controls (Figure 9A). This evidence concerns the gene TOP2A and COVID-19.