Both IL-6 and IL-8 have been reported to be elevated in TRAPS (18), and tocilizumab, an IL-6 receptor antibody, has been reported to be useful as a treatment for patients with TRAPS who have been unsuccessfully treated with TNF inhibitors and IL-1 inhibitors (19–21). The gene discussed is IL1B; the disease is TNF receptor 1-associated periodic fever syndrome.