MEFV and familial Mediterranean fever: Among the proteins of which inflammasomes are composed are pyrin, which is known to be dysfunctional in FMF; nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), which is known to be dysfunctional in CAPS; and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which activates caspase 1.