Figure 6A depicts the mutational landscape of NLncS. APC and TP53 ranked first and second with 79% and 61% mutation frequencies, respectively, which supported that high mutation rates of APC and TP53 might be responsible for giving rise to CRC (Figure 6A). Given that CNV dominatingly consisted of amplification (AMP) and homozygous deletion (HOMDEL), we sequenced the genes by frequency of AMP and HOMDEL (Figure 6B). This evidence concerns the gene TP53 and colorectal carcinoma.