NFE2L2 and synovitis: A paper in 2021 showed that the iron content and the expression of TfR1 and NCOA4 in synovitis cells increased, while the expression of GPX4, SLC7A11, SLC3A2L, and NRF2 decreased in LPS-induced synovitis cell model, resulting in increased synovitis cells death and decreased cell viability (38).