In that paper, the researchers used TNF antagonists combined with IKE to induce ferroptosis of RA-FLSs, which reduced cartilage and bone damage in CIA mice, and they also used an IL-6 antagonist and a TGF-β antagonist to confirm the ferroptosis-regulating function of these two cytokines (39). The gene discussed is TNF; the disease is rheumatoid arthritis.