The association analysis between these identified 966 hub genes and OS of BC patients was then conducted by the univariate Cox regression analysis, finally identifying 62 OS-related hub genes (Supplementary Table 2, p < 0.01), which were further enrolled in the LASSO Cox regression analysis (Figure 3A), and there were 11 genes selected (CERCAM, TPST1, OSBPL10, EMP1, CYTH3, NCRNA00201, PCDH10, GAP43, COLQ, DGKB, and SETBP1) to establish a novel FARG signature (Figure 3B). This evidence concerns the gene EMP1 and breast cancer.