Compared to the healthy controls, patients with COVID-19 had significantly higher circulating concentrations of 19 inflammatory mediators, namely interleukins 1α, 2, 6, 7, 8, 10 and 15, CRP, SAA, ICAM-1, VCAM-1, CXCL10, CCL3, CCL26, IFN-γ, TNF-α, bFGF, PlGF and Flt-1 (P < 0.05, Table 4). This evidence concerns the gene TNF and COVID-19.