On the other hand, tumor cells can attract neutrophils that contribute to the destruction of the basement membranes and the invasion into surrounding tissues (58) through the secretion of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), interleukins IL-6 and IL-8 to promote tumor growth, invasion and metastasis (7). The gene discussed is VEGFA; the disease is neoplasm.