While eculizumab treatment has been approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and neuromyelitis optica spectrum disorders (NMOSDs), C1INH is used for the treatment of hereditary angioedema (96). The gene discussed is SERPING1; the disease is paroxysmal nocturnal hemoglobinuria.