During sepsis, inflammatory cytokines enter the central nervous system through various pathways, including receptor-mediated transcellular action, transcellular diffusion, and carrier proteins (62, 63).Proinflammatory cytokines such as IL-1β, IL-6, and lipopolysaccharide, reactive oxygen species, and NO act on BBB to alter brain function, resulting in the disruption of brain homeostasis and changes in BBB permeability (64–66). The gene discussed is IL6; the disease is Sepsis.