In the context of schistosomiasis, we have previously shown that they play a fundamental role in the priming of CD4+ T cell responses, with depletion of CD11c+ DCs early in murine S. mansoni infection (wks 4 – 6) leading to a stark reduction in splenic and hepatic Th2 cells (IL-4, IL-5, and IL-13) and Tregs (24). This evidence concerns the gene CD4 and schistosomiasis.