Furthermore, mirroring the exaggeration of hepatic pathology during later stages of infection (Figures 1B, C), infected mice displayed significantly higher serum levels of SEA-specific antibodies and IgE by wks 12 and 15 (Supplementary Figures 1E, F), as well as hepatosplenomegaly from wk 8, as defined by increased spleen and liver weight as a proportion of total body weight (Supplementary Figure 1G). This evidence concerns the gene IGHE and infection.