Our results provide a platform for future interrogation of the role of CD11c+ cells in more chronic stages of infection, alongside employment of more targeted CD11c depletion approaches (113), to enable a more holistic understanding of the role and importance of CD11c+ APC subsets in governing immunopathology in effector sites such as the liver over the course of schistosome infection. The gene discussed is ITGAX; the disease is infection.