In line with this, in a model of schistosome egg induced pulmonary granulomatous inflammation, depletion of known eosinophil (105) and Th2 cell (108) chemokines CCL17 and CCL22, which can be produced by DCs (105–107), led to altered granuloma structure, including a dramatic reduction in eosinophilia (109). The gene discussed is CCL17; the disease is Increased total eosinophil count.