Soluble BTLA and TIM-3 were significantly increased for those who developed an infection after thermal injury from those that did not (BTLA: 3998 pg/mL vs 1142 pg/mL; TIM-3: 3225 pg/mL vs 752.1 pg/mL) (Figures 4A, B). This evidence concerns the gene HAVCR2 and infection.