High concentrations of circulating total IL-18 have been reported in several clinical conditions including IBD, sepsis, type 2 diabetes, and atherosclerosis and myocardial infarction (2); however, it appears to date, that dramatic and often chronic elevation of serum IL-18 (> 103–104 pg/ml) are only linked to genetic diseases affecting its release or maybe production and a certain rheumatic disease (i.e., sJIA/AOSD). This evidence concerns the gene IL18 and hereditary disease.