Moreover, the transcriptional levels of IFN-λ including IFN-λ1, IFN-λ3 and IFN-λ4 were diminished markedly in cells transfected with siRIG-I, siMDA5, siMyD88 or siTRIF but not MAVS, compared with the siNC following FJzz1 infection (Figures 5G–I), demonstrating that RIG-I/MDA5-mediated RLRs signaling pathway and MyD88/TRIF-mediated TLRs signaling pathway involved in the production of type III IFNs during FJzz1 infection. The gene discussed is RIGI; the disease is infection.