In pathological state, LAG-3 was reported to be highly expressed on the surface of tumor-infiltrating lymphocytes (TILs), the expression level of which was positively correlated with the occurrence and development of human tumors, such as non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC) (25–27). This evidence concerns the gene LAG3 and hepatocellular carcinoma.