High level of LAG-3 in kidney renal clear cell carcinoma, non-small cell lung cancer (NSCLC), primary central nervous system lymphoma (PCNSL), hepatocellular carcinoma (HCC) and muscle invasive bladder cancer (MIBC) indicates a poor prognosis, whereas in gastric carcinoma and melanoma predicts a better prognosis (12). The gene discussed is LAG3; the disease is hepatocellular carcinoma.