Therefore, in this study, we found a new IR target, namely, IAP, which can dephosphorylate LPS and triphosphate nucleotide by supplementing and activating IAP in the intestinal tract; consequently, intestinal inflammation was controlled, and IR induced by intestinal inflammation was alleviated rather than control the gut microbes to alleviate IR and T2DM as other studies have reported. Here, ALPI is linked to type 2 diabetes mellitus.