Recently, there was a report of a case of a 48-year-old man with ALK+ NSCLC who displayed a complete response for 16 months to nivolumab (PD-1 inhibitor) therapy in a third line setting after ceritinib (second-generation ALK inhibitor) and platin-based chemotherapy (60). The gene discussed is ALK; the disease is non-small cell lung carcinoma.