In contrast to previous reports of WNT5A positively correlating with IL-6 and insulin resistance (44, 45), data from the current study in which metabolic complications are yet to manifest, identifies negative correlations between WNT5A mRNA expression and HOMA2-IR (ρ = -0.480, P = 0.032) and plasma IL-6 concentrations (ρ = -0.445, P = 0.049). The gene discussed is WNT5A; the disease is Insulin resistance.