All in all, we obtained 20 immune DEGs (13 downregulated genes and seven upregulated genes) in VKH disease and finally screened out six immune hub genes (KLRC2, KLRC3 SH2D1B, GZMB, KIR2DL3, and KIR3DL2) associated with VKH disease, some of which have not been mentioned in the present researches of VKH disease until now. Here, KLRC2 is linked to Vogt-Koyanagi-Harada disease.