EDN1 and cardiac hypertrophy: P300 overexpression in mouse cardiomyocytes stimulates the expression of the GATA4-dependent genes related to cardiac hypertrophy, including natriuretic peptide precursor A(Nppa, mediating the translation of ANP), prepro-endothelin-1(ET-1), and β-myosin heavy chain (Myh7) (38).