LRP1 and autosomal dominant cerebellar ataxia: Our results showed that decreased LRP1 expression at cell surface in total monocytes, but not LRP1 mRNA, is associated with a monocyte pro-inflammatory profile in individuals with SCA, characterized by increased levels of TNF-α and IL-1β mRNA, which could contribute to the persistent activation of monocytes as mediators of atherosclerosis development (7).