Compared with the control group, the expression levels of IGKV1-8 and TCL6 in male and female patients with CTEPH were all upregulated trend and PMP22, PIK3R6 and KCNMB2-AS1 were all downregulated trend (Supplementary Figure 1). The gene discussed is PIK3R6; the disease is chronic thromboembolic pulmonary hypertension.