Endothelial dysfunction is usually defined as alterations of the endothelial phenotype characterized by increased oxidative stress, elevated expression of proinflammatory factors, increased expression of ICAM-1 and VCAM-1, insulin resistance, reduced nitric oxide (NO) bioavailability, abnormal vasoreactivity, and so on [21, 22]. The gene discussed is VCAM1; the disease is Insulin resistance.