As shown in Figure 5(a), the VDAC1 phosphorylation level at S104 increased in primary tumor tissues of breast cancer (P = 1.05e − 05), colon cancer (P = 8.6e − 36), lung adenocarcinoma (P = 1.2e − 22), ovarian cancer (P = 1.07e − 02), clear cell renal cell carcinoma (P = 1.7e − 13), and uterine corpus endometrial carcinoma (P = 6.4e − 10), compared with normal tissues. Here, VDAC1 is linked to malignant colon neoplasm.