As mentioned in the above results, a high-fat diet resulted in the increased circulating level of inflammatory marker (C-reactive protein, CRP, Supplementary Figure 1C), lipid peroxidation marker (malondialdehyde, MDA, Supplementary Figure 2D), blood lipids (TC, TG, LDL-C, Figures 1A–C), liver enzymes (ALT, AST, Supplementary Figure 7), and decreased circulating level of HDL-C (Figure 1D), as well as antioxidant activity (SOD, TAOC, GPx, Supplementary Figures 2A–C), which at least partially demonstrated the successful development of an animal model for atherosclerosis. Here, SOD1 is linked to atherosclerosis.