PNPLA2 and Hyperglycemia: Nevertheless, several studies have shown inhibitory effects of anthocyanins on lipolytic activity, along with downregulation of PNPLA2 (also known as adipose triglyceride lipase, ATGL) and PPARG (peroxisome proliferators-activated receptor-γ) under conditions of hyperglycemia and differentiation in preadipocyte 3T3-L1 (35).