KRT18 and steatosis: The reduction in CK-18 levels after the 5:2 diet is not impressive, but, at least, it has a modest clinical magnitude, as we observed a reduction from ~13.2 to 11.9 ng/ml, and a proposed CK-18 cutoff value to detect steatosis (S ≥ 2) in NAFLD is 11.7 ng/ml (53).