TJP1 and necrotizing enterocolitis: In this study, it was found that the proliferation and migration ability of cells was significantly weakened while the expression of ZO-1 protein was downsized after SIRT1 expression was curbed in IEC-6 cells, signifying that SIRT1 could enhance the proliferation and migration ability of intestinal epithelial cells and the expression of ZO-1 to maintain the homeostasis of intestinal epithelial cells and to protect the barrier function to downsize the damage of NEC.